Craig T. Nelson - Bob Parr
Samuel L. Jackson - Lucius Best
Holly Hunter - Helen Parr
Jason Lee - Buddy Pine
Dominique Louis - Bomb Voyage
Teddy Newton - Newsreel Narrator
Jean Sincere - Mrs. Hogenson
Eli Fucile - Jack-Jack Parr
Maeve Andrews - Jack Jack Parr
Wallace Shawn - Gilbert Huph
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