Craig T. Nelson - Bob Parr
Samuel L. Jackson - Lucius Best
Holly Hunter - Helen Parr
Sarah Vowell - Violet Parr
Huck Milner - Dashiell Parr
Catherine Keener - Evelyn Deavor
Eli Fucile - Jack-Jack Parr
Bob Odenkirk - Winston Deavor
Michael Bird - Tony Rydinger
Brad Bird - Edna Mode (E)